Lace up for a meaningful morning at the Miles for Melanoma - Orange County 5K, set to take place on Sunday, February 22, 2026, in the vibrant city of Irvine, CA. This inspiring 5K run/walk, hosted at the scenic Great Park Run located at 8000 Great Park Blvd, brings together a dedicated community of patients, survivors, caregivers, and supporters, all united in the fight against melanoma. As a nationwide series of events, Miles for Melanoma is a cornerstone fundraiser for the Melanoma Research Foundation, actively transforming one of the deadliest cancers into one of the most treatable through vital research, education, and advocacy.

The event site opens at 7:30 AM PT, with opening ceremonies commencing at 8:30 AM PT before the 5K officially begins at 9:00 AM PT. Participants can anticipate typical race day conditions with comfortable highs around 68°F and lows near 50°F, accompanied by a minimal 6% chance of precipitation, making for ideal running weather. While the official 5K route map is typically available closer to race day, the Great Park setting promises an accessible and enjoyable course. Aid stations with water will be strategically placed along the route to keep runners hydrated and motivated.

Beyond the run itself, the Miles for Melanoma - Orange County offers a welcoming atmosphere complete with various activities, including a photo booth, sponsor booths with giveaways such as sunscreen and tote bags, outdoor games, and a kids' activity packet. All registered in-person participants receive a premium Coolibar UPF 50+ shirt, emphasizing sun safety. This rain-or-shine event is also proudly pet-friendly, encouraging everyone to join in support of this critical cause. Free parking is available on-site, ensuring a smooth start and finish to an impactful day.