The River to River Relay, set for April 18, 2026, offers an unparalleled 80-mile team adventure across the picturesque southern tip of Illinois, from the mighty Mississippi River to the historic Ohio. Established in 1987, this iconic relay has grown into a cherished tradition, annually drawing over 2,000 runners from across the Midwest and beyond. Teams of eight conquer a challenging course known for its demanding elevation changes, winding through the rolling hills and dense forests of the Shawnee National Forest, along country roads (mostly paved, with some gravel sections), and past charming rural communities. Typical race day conditions in April offer pleasant highs around 69°F and lows around 43°F, with a modest 21% chance of precipitation, creating ideal running weather for most teams.

The course is a test of both individual endurance and collective strategy, with each runner completing three legs ranging from 2.5 to 4 miles. The journey begins atop McGee Hill in LaRue Pine Hills near Wolf Lake, offering misty, scenic views of the Mississippi River Valley, and concludes triumphantly at the Ohio River in Golconda, near the Pope County Courthouse. Runners frequently praise the race's unique blend of strenuous effort, teamwork, and camaraderie. Expect everything from challenging climbs, like the infamous Section 22, to breathtaking scenery including redbud trees and glimpses of the Southern Illinois Wine Trail.

What truly sets the River to River Relay apart is its vibrant atmosphere. Runners describe it as exhilarating, exhausting, and unforgettable, fostering deep bonds within teams as they travel together in vans between 23 exchange zones. The supportive community spirit shines through, with local residents cheering on participants and volunteers staffing aid stations along the route. Upon crossing the finish line as a team, the euphoria is palpable, leading into post-race festivities featuring live music, food vendors, and even massage tables, celebrating a shared accomplishment that many recall as one of their top running memories.