Run for 21

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Lace up for a meaningful journey at the Run for 21, taking place on Sunday, June 7, 2026, in the heart of St. Louis, Missouri. This unique 3.21-mile race, symbolically representing the third copy of the twenty-first chromosome, is more than just a run; it's a vibrant celebration of individuals with Down syndrome. All proceeds directly benefit the Gateway Down Syndrome Association (GDSA), supporting their vital programs and initiatives. It's an inspiring event that fosters community and raises crucial awareness in a truly engaging way.

The scenic course winds through beautiful Forest Park, offering a refreshing backdrop for runners and walkers alike. The race begins and concludes at the Upper Muny Parking Lot, providing a central hub for all the excitement. Typical race day conditions in early June for St. Louis see comfortable highs around 85F and lows around 64F, with a modest 16% chance of precipitation, creating a pleasant atmosphere for your efforts.

What truly sets the Run for 21 apart is its festive spirit. The event coincides with the GDSA's largest annual celebration, "Step Up for Down Syndrome," ensuring an energetic and supportive environment. Participants receive a race shirt and a finisher medal, and a highlight for many is the unlimited pancake breakfast by Chris Cakes awaiting you at the finish line. The race welcomes all, including leashed dogs and strollers (kindly lining up at the back), making it a perfect, inclusive event for families and friends to come together for a fantastic cause.

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